The whole of Mozambique is a malaria area and recommended prophylaxis should be taken. Your doctor can advise you on the best type for the area of travel and your personal requirements. However, taking prophylaxis will not guarantee that you will not contract malaria! The best way to avoid malaria is to avoid being bitten by the mosquitoes that carry the parasite. Only the females of one species of mosquito carry the tiny parasite, and the greatest incidence of malaria is in areas of high population where there are many people for the mosquito to bite and pass the parasite between.
Mosquitoes usually bite between sunset and sunrise, so make sure that you are covered up during this time! Wear loose fitting, long sleeved shirts and trousers, use a good insect repellent and sleep underneath a mosquito net or in a tent/ room sealed with netting. If you do develop flu-like symptoms, or feel at all unwell, during your holiday or after your return home, you must make sure that your doctor knows that you have recently travelled in a malaria area. Malaria is not a serious problem provided people take adequate precautions and seek advice and treatment immediately if they feel unwell.
Maputo's private hospitals are of a good standard with clean and safe facilities. However, serious medical cases will be evacuated by air to South Africa where further facilities are available. For this reason you must make sure that comprehensive travel insurance is taken out before you travel, this insurance should cover any medical expenses, air evacuation and repatriation if necessary.